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KMID : 0358319960370111227
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Korean Journal of Urology
1996 Volume.37 No. 11 p.1227 ~ p.1233
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Detection of Interleukin 2 In Urine of Patients with Superficial Bladder Tumors after Intravesical BCG Theraph
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Abstract
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Intravesical Bacillus Calmette-Guerin (BCG0 therapy is an effective immunotherapy used for the treatment and dprophylaxis of superficial bladder cancer. The mechanism through which BCGD exerts its antitumor activity is not fully understood.
However,
several studies suggest that antitumor mechanism of BCG is assocciated with T-cell mediated immunity and lymphokines. In this report, the detection of IL-2(a lymphokine produced in response to BCG0 in urine and serum specimens of patients treated
with
intravesical BCG is reported.
Urine specimens of 10 superficial bladder cancers were obtained prior to BCG instillation, 4 8, and 24 hours afterwards. Serum specimens of same patients were obtained before and 8 hours after BCG instillation. No change of serum IL-2 before and
after
BCG instillation were observed. Urinary IL-2 production increased significantly 4 and 8 hours (p<0.05) and decreased 24 hours after BCG instillation were similar to baseline values. Between urinary IL-2 of healthy men and cystitis patients were
similar.
These results suggest that BCG induce IL-2 production with highest level at 4 hours after BCG instillation and IL-2 might play a important role in antitumor mechanism of BCG however, further studies are necessary to elucidate the antitumor
mechanism of
BCG.
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KEYWORD
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